Recent advances in several areas are rekindling interest and enabling progress in the
development of therapeutic cancer vaccines. These advances have been made in target …

The concept of stimulating the body's immune response is the basis underlying vaccination.
Vaccines act by initiating the innate immune response and activating antigen presenting …

Introduction: Adjuvants are used to improve vaccine immunogenicity and efficacy by
enhancing antigen presentation to antigen-specific immune cells with the aim to confer long …

Both the innate and adaptive immune systems decline with age, causing greater
susceptibility to infectious diseases and reduced responses to vaccination. Diseases are …

Previously, the contribution of peripheral infection to cognitive decline was largely
overlooked however, the past 15 years have established a key role for infectious pathogens …

Many candidate biomarkers of human ageing have been proposed in the scientific literature
but in all cases their variability in cross-sectional studies is considerable, and therefore no …

A diverse T cell repertoire is essential for a vigorous immune response to new infections,
and decreasing repertoire diversity has been implicated in the age-associated decline in …

Immunosenescence is a term used to describe the age-related changes in the immune
system. Immunosenescence is associated with complex alterations and dysregulation of …

Background T cell-mediated immunity in elderly people is compromised in ways reflected in
the composition of the peripheral T cell pool. The advent of polychromatic flow cytometry has …

Abstract 'Immunosenescence'is an imprecise term used to describe deleterious age‐
associated changes to immune parameters observed in all mammals studied so far …