Why does the thymus involute? A selection-based hypothesis

MR Dowling, PD Hodgkin - Trends in immunology, 2009 - cell.com
Thymic involution remains a fundamental mystery in immunology. Here we present an
argument that this seemingly counterproductive behavior may have evolved to allow for …

[HTML][HTML] Importance of adjuvant selection in tuberculosis vaccine development: Exploring basic mechanisms and clinical implications

HG Choi, KW Kwon, SJ Shin - Vaccine: X, 2023 - Elsevier
The global emergency of unexpected pathogens, exemplified by SARS-CoV-2, has
emphasized the importance of vaccines in thwarting infection and curtailing the progression …

Effectiveness of the vaccine (Covaxin®) on different age groups of people: A pilot study

V Chauhan, A Rakshit, VK Dhiman, G Mahajan… - Vacunas, 2024 - Elsevier
Background Covaxin® is a COVID-19 vaccine created and produced by Bharat Biotech in
India. The vaccine is based on the strain of SARS-CoV-2 that was first identified in India and …

[HTML][HTML] Declining prevalence of SARS-cov-2 antibodies among vaccinated nursing home residents and staff six months after the primary bnt162b2 vaccination …

E Meyers, E Deschepper, E Duysburgh, L De Rop… - Viruses, 2022 - mdpi.com
In the SCOPE study, we monitored SARS-CoV-2 antibodies in a national sample of
residents and staff from Belgian nursing homes. Here, we report the seroprevalence among …

[HTML][HTML] Adipose-derived mesenchymal stem cells restore impaired mucosal immune responses in aged mice

K Aso, A Tsuruhara, K Takagaki, K Oki, M Ota, Y Nose… - PLoS …, 2016 - journals.plos.org
It has been shown that adipose-derived mesenchymal stem cells (AMSCs) can differentiate
into adipocytes, chondrocytes and osteoblasts. Several clinical trials have shown the ability …

Adjuvants that stimulate TLR3 or NLPR3 pathways enhance the efficiency of influenza virus-like particle vaccines in aged mice

K Schneider-Ohrum, BM Giles, HK Weirback… - Vaccine, 2011 - Elsevier
There is intense interest in the design and use of vaccine strategies against influenza to
enhance protective immune responses in the elderly. To address the need for improved …

Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge

Z Wen, L Ye, Y Gao, L Pan, K Dong, Z Bu… - Antiviral research, 2009 - Elsevier
Influenza virus-like particles (VLPs) were produced in Sf9 insect cells by co-expressing the
matrix protein M1 and the surface glycoproteins hemagglutinin (HA) and neuraminidase …

Advocating vaccination of adults aged 60 years and older in Western Europe: statement by the joint Vaccine Working Group of the European Union Geriatric Medicine …

JP Michel, C Chidiac, B Grubeck-Loebenstein… - Rejuvenation …, 2009 - liebertpub.com
Vaccines are an underused public health strategy for healthy aging. Considering the risks of
vaccine-preventable diseases and the current low vaccine coverage rates in older European …

Aging and HIV infection

VI Avelino-Silva, YL Ho, TJ Avelino-Silva… - Ageing research …, 2011 - Elsevier
INTRODUCTION: Population aging has become a global phenomenon, and HIV infection
among older individuals is also increasing. Because age can affect the progression of HIV …

Susceptibility of the aging lung to environmental injury

L Wang, FHY Green, SM Smiley-Jewell… - … in Respiratory and …, 2010 - thieme-connect.com
With an ever-increasing number of elderly individuals in the world, a better understanding of
the issues associated with aging and the environment is needed. The respiratory system is …