The emergence of the three germ layers and the lineage-specific precursor cells
orchestrating organogenesis represent fundamental milestones during early embryonic …

Mouse models are a critical tool for studying human diseases, particularly developmental
disorders. However, conventional approaches for phenotyping may fail to detect subtle …

The assembly of the neuronal and other major cell type programs occurred early in animal
evolution. We can reconstruct this process by studying non-bilaterians like placozoans …

Early organogenesis represents a key step in animal development, during which pluripotent
cells diversify to initiate organ formation. Here, we sampled 300,000 single-cell …

Commitment to specific cell lineages is critical for mammalian embryonic development.
Lineage determination, differentiation, maintenance, and organogenesis result in diverse life …

The house mouse, Mus musculus, is an exceptional model system, combining genetic
tractability with close homology to human biology. Gestation in mouse development lasts …

Single-cell sequencing is a powerful approach that can detect genetic alterations and their
phenotypic consequences in the context of human development, with cellular resolution …

Organogenesis requires the orchestrated development of multiple cell lineages that
converge, interact, and specialize to generate coherent functional structures, exemplified by …

To respond to the world around them, animals rely on the input of a network of sensory
organs distributed throughout the body. Distinct classes of sensory organs are specialized …

The hourglass model describes the convergence of species within the same phylum to a
similar body plan during development; however, the molecular mechanisms underlying this …