In animal cells, molecular pathways often comprise families of variant components, such as
ligands or receptors. These pathway components are differentially expressed by different …

Quantifying the number of progenitor cells that found an organ, tissue or cell population is of
fundamental importance for understanding the development and homeostasis of a …

Clonal evolution has gained immense attention in explaining cancer cell status, history, and
fate during cancer progression. Current single-cell or spatial transcriptome technologies …

Transcription factors with basic-helix-loop-helix (bHLH) motifs can control neural progenitor
fate determination to neurons and oligodendrocytes. How bHLH transcription factors …

Tracing developmental lineages | Nature Methods Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Single-cell genomics technologies enable multimodal profiling of millions of cells across
temporal and spatial dimensions. Experimental limitations prevent the measurement of all …

Proper differentiation of corneal epithelial cells (CECs) from limbal stem/progenitor cells
(LSCs) is required for maintenance of ocular homeostasis and clear vision. Here, using a …

Experimental approaches for measuring single-cell gene expression can observe each cell
at only one time point, requiring computational approaches for reconstructing the dynamics …

Cataloging the diverse cellular architecture of the primate brain is crucial for understanding
cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell …

The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …