Accurately identifying cell-populations is paramount to the quality of downstream analyses
and overall interpretations of single-cell RNA-seq (scRNA-seq) datasets but remains a …

Metacells are cell groupings derived from single-cell sequencing data that represent highly
granular, distinct cell states. Here, we present single-cell aggregation of cell-states …

Drosophila melanogaster is a powerful, long-standing model for metazoan development and
gene regulation. We profiled chromatin accessibility in almost 1 million and gene expression …

In vivo differentiation of human pluripotent stem cells (hPSCs) has unique advantages, such
as multilineage differentiation, angiogenesis, and close cell-cell interactions. To …

Mammalian embryos exhibit sophisticated cellular patterning that is intricately orchestrated
at both molecular and cellular level. It has recently become apparent that cells within the …

Highlights•Single-cell atlases of mouse embryogenesis reveal epigenetic regulator
dynamics in early development.•Genetic perturbation in combination with single-cell …

Stem cells differentiate into distinct fates by transitioning through a series of transcriptional
states. Current computational approaches allow reconstruction of differentiation trajectories …

Progesterone treatment is commonly employed to promote and support pregnancy. While
maternal tissues are the main progesterone targets in humans and mice, its receptor (PGR) …

We provide here a detailed single cell transcriptomic atlas covering the life cycle of the
cosmopolitan scyphozoan Aurelia coerulea. We show that there is an increase in cell type …

Abstract The Cre-LoxP system has been commonly used for cell-specific genetic
manipulation. However, many Cre strains exhibit excision activity in unexpected cell types or …