Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of cell fate in
developmental systems. However, identifying the molecular hallmarks of potency-the …

The early developmental phase is of critical importance for human health and disease later
in life. To decipher the molecular mechanisms at play, current biomedical research is …

Early mammalian gastrulations cell-fate decisions are poorly understood due to difficulties
obtaining non-rodent embryos. The bilaminar disc of pig embryos mirrors humans, making …

Mouse models are a critical tool for studying human diseases, particularly developmental
disorders, as well as for advancing our general understanding of mammalian biology …

The fast-growing single-cell analysis community extends the horizon of quantitative analysis
to numerous computational tasks. While the tasks hold vastly different targets from each …

Understanding the composition and function of cells constituting tissues and organs is vital
for unraveling biological processes. Single-cell analysis has allowed us to move beyond …

The explosive growth of regulatory hypotheses from single-cell datasets demands accurate
prioritization of hypotheses for in vivo validation. However, current computational methods …

Embryonic stem cells (ESCs) can self-organize in vitro into developmental patterns with
spatial organization and molecular similarity to that of early embryonic stages. This self …

The emergence of single-cell time-series datasets enables modeling of changes in various
types of cellular profiles over time. However, due to the disruptive nature of single-cell …

The inherent limitations of fluorescence microscopy, notably the restricted number of color
channels, have long constrained comprehensive spatial analysis in biological specimens …