Cancer therapeutics are often highly toxic to the patient, and they often elicit rapid resistance
in the tumour. Recent advances have suggested a potential new way in which we may …

Embryonic organoids are emerging as powerful models for studying early mammalian
development. For example, stem cell-derived'gastruloids' form elongating structures …

Single-cell transcriptomics has revealed conserved and divergent programmes of
organogenesis in mammals, but existing studies have focused on eutherians. Marsupials …

Closure of the neural tube represents a highly complex and coordinated process, the failure
of which constitutes common birth defects. The serine/threonine kinase p21‐activated …

The spinal cord, nerves, and skeletal muscles arise from neuromesodermal progenitors
(NMPs). We have developed a growth-factor screening strategy, utilizing ES and iPS cells …

The mammalian heart is formed from multiple mesoderm-derived cell lineages. However, it
remains largely unknown when and how the specification of mesoderm towards cardiac …

Microscopy and omics are complementary approaches to probe the molecular state of cells
in health and disease, combining granularity with scalability. While important advances have …

The homeostasis of the transparent corneal epithelium in the eye is maintained by limbal
stem cells with proper cell fates. A potential disease mechanism underlying corneal opacity …

Understanding the diversification of mammalian cell lineages is an essential to embryonic
development, organ regeneration and tissue engineering. Shortly after implantation in the …

Single-cell atlases are critical for unraveling the cellular basis of health and disease, yet
their sheer diversity and vast data landscape in time and space pose daunting …