Many single-cell RNA-sequencing studies have collected time-series data to investigate
transcriptional changes with respect to various notions of biological time, such as cell …

The regulatory mechanisms governing cell fate determination, particularly lineage
diversification during mammalian embryonic development, remain poorly understood with in …

Human liver endothelial cells (HLEC) line the hepatic sinusoids and are reported to have
specialized functions, which underscores their importance in human physiology …

Cells are the fundamental structural and functional units of life. Studying the definition and
composition of different cell types can help us understand the complex mechanisms …

Recent advances in spatial transcriptomics technology have produced full-transcriptomic
scale dataset with subcellular spatial resolutions. Here we present a new computational …

To respond to the world around them, animals rely on the input of a network of sensory
organs distributed across the body. A single individual will generally express several distinct …

Accurately identifying cell populations is paramount to the quality of downstream analyses
and overall interpretations of single-cell RNA-seq (scRNA-seq) datasets but remains a …

Understanding the temporal dynamics of gene expression is crucial for developmental
biology, tumor biology, and biogerontology. However, some time points remain challenging …

Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin's
lymphoma. Many efforts have characterised DLBCL subtypes that account for some of the …

The assembly of the neuronal and other major cell type programs occurred early in animal
evolution. We can reconstruct this process by studying non-bilaterians like placozoans …