Cell fate decision remains poorly understood at the molecular level. Embryogenesis
provides a unique opportunity to analyse molecular details associated cell fate decisions …

The emergence of multiple, stable cell lineages from a single-cell zygote is the essence of
multicellular development. Combinatorial transcription factor expression is central to this …

Advancements in transcriptomic technologies have enabled the measurement of gene
expression at single cell resolution and provided spatial localization information on tissues …

Quantifying the number of progenitor cells that founder an organ, tissue or cell population is
of fundamental value for understanding the development and homeostasis of a multicellular …

Angiogenesis is a process to generate new blood vessels from pre-existing vessels and to
maintain vessels, and plays critical roles in normal development and disease. However, the …

The separation of embryonic and extraembryonic lineages is a process that has evolved in
amniotes to adapt for fetus survival on land. One of the major roles of the extraembryonic …

Recent advances in single-cell RNA sequencing assays have opened the door to
understanding biological heterogeneity at the cellular level, offering new insights into the …

The hourglass model describes the convergence of species within the same phylum to a
similar body plan during development, yet the molecular mechanisms underlying this …

RNA velocity has provided a promising approach for inferring cellular state transition from
single-cell RNA sequencing (scRNA-seq) data. Conventional RNA velocity models infer …