There is an urgent need for strategies to combat dengue virus (DENV) infection; a major
global threat. We reported that the cellular kinases AAK1 and GAK regulate intracellular …

Several recent studies have indicated that miR-30a plays critical roles in various biological
processes and diseases. However, the mechanism of miR-30a participation in idiopathic …

Protein kinases and their substrates form signaling networks partitioned across subcellular
compartments to facilitate critical biological processes. While the subcellular roles of many …

The combination of methotrexate with epidermal growth factor receptor (EGFR) recombinant
antibody, cetuximab, is currently being investigated in treatment of head and neck …

Patients treated with dabrafenib/trametinib (DAB/TRA) exhibit a large interindividual
variability in clinical outcomes. The aims of this study were to characterize the …

Background Vascular endothelial (VE)-cadherin is an endothelial cell-specific protein
responsible for endothelium integrity. Its adhesive properties are regulated by post …

Immunophenotyping on the molecular and cellular level is a central aspect for
characterization of patients with inflammatory diseases, both to better understand disease …

Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs
(lncRNAs), play increasingly important roles in pathological processes involved in disease …

In the era of precision medicine, research of biomarkers for identification of responders to
nivolumab therapy is a major challenge. Peripheral blood mononuclear cells (PBMC) could …

Identifying novel drug-target interactions (DTIs) is a crucial step in drug discovery. Since
experimentally determining DTIs is expensive and time-consuming, it becomes popular to …