FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Background: The gene FOXO3, encoding the transcription factor forkhead box O-3 (FoxO3),
is one of only two for which genetic polymorphisms have exhibited consistent associations …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

Background. The genetic contribution to longevity in humans has been estimated to range
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with …

Several epidemiological studies show an inverse association between cancer and
Alzheimer's disease (AD). It is debated whether this association is the consequence of …

Studies of long-lived individuals have revealed few genetic mechanisms for protection
against age-associated disease. Therefore, we pursued genome sequencing of a related …

Several pathologies such as neurodegeneration and cancer are associated with aging,
which is affected by many genetic and environmental factors. Healthy aging conceives …