Sex differences in biological aging with a focus on human studies

S Hägg, J Jylhävä - Elife, 2021 - elifesciences.org
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

Differences between men and women in mortality and the health dimensions of the morbidity process

EM Crimmins, H Shim, YS Zhang, JK Kim - Clinical chemistry, 2019 - academic.oup.com
BACKGROUND Do men have worse health than women? This question is addressed by
examining sex differences in mortality and the health dimensions of the morbidity process …

Adaptive homeostasis and the free radical theory of ageing

LCD Pomatto, KJA Davies - Free Radical Biology and Medicine, 2018 - Elsevier
Abstract The Free Radical Theory of Ageing, was first proposed by Denham Harman in the
mid-1950's, based largely on work conducted by Rebeca Gerschman and Daniel Gilbert. At …

The role of declining adaptive homeostasis in ageing

LCD Pomatto, KJA Davies - The Journal of physiology, 2017 - Wiley Online Library
Adaptive homeostasis is “the transient expansion or contraction of the homeostatic range for
any given physiological parameter in response to exposure to sub‐toxic, non‐damaging …

The role of oxidative stress in anxiety disorder: cause or consequence?

AG Fedoce, F Ferreira, RG Bota… - Free radical …, 2018 - Taylor & Francis
Anxiety disorders are the most common mental illness in the USA affecting 18% of the
population. The cause (s) of anxiety disorders is/are not completely clear, and research in …

Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration

TW Andrew, LS Koepke, Y Wang, M Lopez… - Nature …, 2022 - nature.com
Sexually dimorphic tissues are formed by cells that are regulated by sex hormones. While a
number of systemic hormones and transcription factors are known to regulate proliferation …

[HTML][HTML] Sex differences in the response to oxidative and proteolytic stress

J Tower, LCD Pomatto, KJA Davies - Redox biology, 2020 - Elsevier
Sex differences in diseases involving oxidative and proteolytic stress are common, including
greater ischemic heart disease, Parkinson disease and stroke in men, and greater …

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom

P Stenvinkel, J Painer, M Kuro-o, M Lanaspa… - Nature Reviews …, 2018 - nature.com
Many of the> 2 million animal species that inhabit Earth have developed survival
mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration …

[HTML][HTML] Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology

J Tiberi, V Cesarini, R Stefanelli, S Canterini… - Mechanisms of ageing …, 2023 - Elsevier
Reactive oxygen species (ROS) is a term that defines a group of unstable compounds
derived from exogenous sources or endogenous metabolism. Under physiological …

The Oxygen Paradox, the French Paradox, and age-related diseases

JMS Davies, J Cillard, B Friguet, E Cadenas, J Cadet… - GeroScience, 2017 - Springer
A paradox is a seemingly absurd or impossible concept, proposition, or theory that is often
difficult to understand or explain, sometimes apparently self-contradictory, and yet ultimately …