Abstract Changes in gene expression are involved in many brain functions. Epigenetic
processes modulate gene expression by histone modification and DNA methylation or RNA …

Chronological age is the most important risk factor for the incidence of age-related diseases.
The pace of ageing determines the magnitude of that risk and can be expressed as …

The gut-brain axis involves several bidirectional pathway communications including
microbiome, bacterial metabolites, neurotransmitters as well as immune system and is …

The evidence for physical activity (PA) as a major public health preventive approach and a
potent medical therapy has increased exponentially in the last decades. The biomolecular …

People with ovaries experience reproductive aging as their reproductive function and
system declines. This has significant implications for both fertility and long-term health, with …

Cardiorespiratory fitness (CRF) not only reflects an individual's capacity to perform physical
activities but also encapsulates broader effects on the basic biology of aging. This review …

Biological clock technologies are designed to assess the acceleration of biological age (B-
age) in diverse cell types, offering a distinctive opportunity in toxicogenomic research to …

Geroscience has emerged as a field focusing on interventions to attenuate molecular
changes associated with aging. While lifestyle modifications, medications, and social factors …

Background Biological aging exhibits heterogeneity across multi organ systems. However, it
remains unclear how is lifestyle associated with overall and organ-specific aging and which …

The presence of an appreciable number of senescent cells causes age-related pathologies
as their removal by genetic or pharmacological means, as well as possibly by exercise …