[HTML][HTML] Using MetaboAnalyst 5.0 for LC–HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data

Z Pang, G Zhou, J Ewald, L Chang, O Hacariz… - Nature protocols, 2022 - nature.com
Liquid chromatography coupled with high-resolution mass spectrometry (LC–HRMS) has
become a workhorse in global metabolomics studies with growing applications across …

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

H Sies, VV Belousov, NS Chandel, MJ Davies… - … Reviews Molecular Cell …, 2022 - nature.com
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

[PDF][PDF] Hallmarks of response, resistance, and toxicity to immune checkpoint blockade

G Morad, BA Helmink, P Sharma, JA Wargo - Cell, 2021 - cell.com
Unprecedented advances have been made in cancer treatment with the use of immune
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …

MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights

Z Pang, J Chong, G Zhou… - Nucleic acids …, 2021 - academic.oup.com
Since its first release over a decade ago, the MetaboAnalyst web-based platform has
become widely used for comprehensive metabolomics data analysis and interpretation …

[HTML][HTML] Next-generation sequencing: insights to advance clinical investigations of the microbiome

CR Wensel, JL Pluznick, SL Salzberg… - The Journal of clinical …, 2022 - Am Soc Clin Investig
Next-generation sequencing (NGS) technology has advanced our understanding of the
human microbiome by allowing for the discovery and characterization of unculturable …

Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Z Celebi Sozener, B Ozdel Ozturk, P Cerci, M Turk… - Allergy, 2022 - Wiley Online Library
Environmental exposure plays a major role in the development of allergic diseases. The
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …

Potential human health risks due to environmental exposure to nano-and microplastics and knowledge gaps: A scoping review

A Rahman, A Sarkar, OP Yadav, G Achari… - Science of the Total …, 2021 - Elsevier
Microplastics are an emerging global environmental contaminant that are affecting multiple
spheres. Despite their ubiquity in all spheres of life and ecology, little is known about the …

[HTML][HTML] Networks beyond pairwise interactions: Structure and dynamics

F Battiston, G Cencetti, I Iacopini, V Latora, M Lucas… - Physics Reports, 2020 - Elsevier
The complexity of many biological, social and technological systems stems from the richness
of the interactions among their units. Over the past decades, a variety of complex systems …

[PDF][PDF] Hallmarks of health

C López-Otín, G Kroemer - Cell, 2021 - cell.com
Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan

A Agustí, E Melen, DL DeMeo… - The Lancet …, 2022 - thelancet.com
The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted
disease caused by tobacco smoking in genetically susceptible individuals has been …