[HTML][HTML] Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes?
The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …
has many connections with other systems and is, in fact, often considered as part of the …
[HTML][HTML] Aging hallmarks and the role of oxidative stress
E Maldonado, S Morales-Pison, F Urbina, A Solari - Antioxidants, 2023 - mdpi.com
Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …
function of the organism and an increased risk of age-related chronic diseases such as …
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm
Biological aging is the gradual, progressive decline in system integrity that occurs with
advancing chronological age, causing morbidity and disability. Measurements of the pace of …
advancing chronological age, causing morbidity and disability. Measurements of the pace of …
A synopsis on aging—Theories, mechanisms and future prospects
Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …
life itself. There are countless theories as to why and how we age, but, until recently, the very …
Omics sciences for systems biology in Alzheimer's disease: State-of-the-art of the evidence
Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
[HTML][HTML] COVID-19 disease severity and death in relation to vitamin D status among SARS-CoV-2-positive UAE residents
Insufficient blood levels of the neurohormone vitamin D are associated with increased risk of
COVID-19 severity and mortality. Despite the global rollout of vaccinations and promising …
COVID-19 severity and mortality. Despite the global rollout of vaccinations and promising …
Small-magnitude effect sizes in epigenetic end points are important in children's environmental health studies: the children's environmental health and disease …
Background: Characterization of the epigenome is a primary interest for children's
environmental health researchers studying the environmental influences on human …
environmental health researchers studying the environmental influences on human …
Biomarker signatures of aging
P Sebastiani, B Thyagarajan, F Sun, N Schupf… - Aging cell, 2017 - Wiley Online Library
Because people age differently, age is not a sufficient marker of susceptibility to disabilities,
morbidities, and mortality. We measured nineteen blood biomarkers that include …
morbidities, and mortality. We measured nineteen blood biomarkers that include …
[HTML][HTML] Where metabolism meets senescence: focus on endothelial cells
Despite the decline in their proliferative potential, senescent cells display a high metabolic
activity. Senescent cells have been shown to acquire a more glycolytic state even in …
activity. Senescent cells have been shown to acquire a more glycolytic state even in …
The brain, sirtuins, and ageing
A Satoh, S Imai, L Guarente - Nature Reviews Neuroscience, 2017 - nature.com
In mammals, recent studies have demonstrated that the brain, the hypothalamus in
particular, is a key bidirectional integrator of humoral and neural information from peripheral …
particular, is a key bidirectional integrator of humoral and neural information from peripheral …