Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
[HTML][HTML] Vaccination in the elderly: the challenge of immune changes with aging
The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …
morbidity and mortality making vaccination a crucial mean to safeguard this population …
[PDF][PDF] Geroscience: linking aging to chronic disease
Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches.
Given that the elderly population is dramatically increasing and that aging is the greatest risk …
Given that the elderly population is dramatically increasing and that aging is the greatest risk …
[HTML][HTML] Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study
M Puzianowska-Kuźnicka, M Owczarz… - Immunity & …, 2016 - Springer
Background In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for
the development of aging-related diseases and frailty. Using data from several thousand …
the development of aging-related diseases and frailty. Using data from several thousand …
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
We use a genome-wide association of 1 million parental lifespans of genotyped subjects
and data on mortality risk factors to validate previously unreplicated findings near CDKN2B …
and data on mortality risk factors to validate previously unreplicated findings near CDKN2B …
[图书][B] Lebensphase hohes Alter: Verletzlichkeit und Reife
A Kruse - 2017 - Springer
Die vorliegende Schrift verfolgt das Ziel, das hohe Alter aus zwei Perspektiven zu
betrachten: einer Verletzlichkeits-und einer Reife-oder Potenzialperspektive. Sie versteht …
betrachten: einer Verletzlichkeits-und einer Reife-oder Potenzialperspektive. Sie versteht …
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
The genetic contribution to the variation in human lifespan is∼ 25%. Despite the large
number of identified disease-susceptibility loci, it is not known which loci influence …
number of identified disease-susceptibility loci, it is not known which loci influence …
[HTML][HTML] DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility
S Ambatipudi, S Horvath, F Perrier, C Cuenin… - European journal of …, 2017 - Elsevier
Aim of the study A vast majority of human malignancies are associated with ageing, and age
is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing …
is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing …
[HTML][HTML] Do people living with HIV experience greater age advancement than their HIV-negative counterparts?
D De Francesco, FW Wit, A Bürkle, S Oehlke… - Aids, 2019 - journals.lww.com
Objectives: Despite successful antiretroviral therapy, people living with HIV (PLWH) may
show signs of premature/accentuated aging. We compared established biomarkers of aging …
show signs of premature/accentuated aging. We compared established biomarkers of aging …
[HTML][HTML] Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Background Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in
humans remains poorly understood. While DNA methylation at many CpG sites closely …
humans remains poorly understood. While DNA methylation at many CpG sites closely …