Telomeres are specialised structures at the end of linear chromosomes. They consist of
tandem repeats of the hexanucleotide sequence TTAGGG, as well as a protein complex …

Normal ageing is associated with diverse physiological changes in all organ systems but the
rate and extent of these changes vary markedly among individuals. One aspect of ageing …

Mammalian aging can be delayed with genetic, dietary and pharmacologic approaches.
Given that the elderly population is dramatically increasing and that aging is the greatest risk …

Research into the genetic component of human longevity can provide important insights in
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …

Background: Human leukocyte telomere length (LTL) decreases with age and shorter LTL
has previously been associated with increased prospective mortality. However, it is not clear …

In the study of longevity, increasing importance is being placed on the concept of healthy
aging rather than considering the total number of years lived. Although the concept of …

Epigenetic remodeling is one of the major features of the aging process. We recently
demonstrated that DNA methylation of ELOVL2 and FHL2 CpG islands is highly correlated …

The role of classical lipids in aging diseases and human longevity has been widely
acknowledged. Triglyceride and cholesterol concentrations are clinically assessed to infer …

Ageing, one of the largest risk factors for many complex diseases, is highly interconnected to
metabolic processes. Investigating the changes in metabolite concentration during ageing …

Human ageing is an extremely personal process leading across the life course of individuals
to large population heterogeneity in the decline of functional capacity, health and lifespan …