Developing strategies to cope with increase in the ageing population and age-related
chronic diseases is one of the societies biggest challenges. The characteristics of the ageing …

Zusammenfassung Am Beginn meiner Beschäftigung mit dem Thema Verletzlichkeit, Reife
und Sorgekultur, meiner Betrachtung des alten Menschen als Gebenden und Nehmenden …

Dentro de una célula coexisten diferentes tipos de biomoléculas que participan en
intrincadas redesde interacciones físicas y bioquímicas. Las mismas facilitan la …

Aging is a ubiquitous process pertaining to all biological systems around the planet.
Although much has been learned from studies so far on the molecular mechanisms that lead …

Cancer is a global public health problem that presents increased prevalence in the elderly.
This is partly because cancer and ageing are processes that share common mechanisms …

Although numerous genetic variants affecting aging and mortality have been identified, for
example, apolipoprotein E ε4, the genetic component influencing cognitive aging has not …

The aim of this thesis was to develop stateof-the-art integrative algorithms for the
comprehensive and robust analysis of omics data sets and to apply them to elucidate …

Résumé Le vieillissement est caractérisé par des changements moléculaires, cellulaires et
fonctionnels. Plusieurs études ont démontré la contribution des facteurs génétiques dans ce …

Ageing is a highly complex biological process with multicausal features that encompass
genetics, biology, and evolution. Advances in human genomics, proteomics, and …

Limited lifespan and senescence are near-universal phenomena. These quantitative traits
exhibit variation in natural populations due to the segregation of many interacting loci and …