Ageing is a complex biological process associated with increased morbidity and mortality.
Nine classic, interdependent hallmarks of ageing have been proposed involving genetic and …

Exercise has long been acknowledged for its powerful disease-preventing, health-promoting
effects. However, the cellular and molecular mechanisms responsible for the beneficial …

By satisfying bioenergetic demands, generating biomass, and providing metabolites serving
as cofactors for chromatin modifiers, metabolism regulates adult stem cell biology. Here, we …

Mice are often used in gain or loss of function studies to understand how genes regulate
metabolism and adaptation to exercise in skeletal muscle. Once-daily resistance training …

Genesis of skeletal muscle relies on the differentiation and fusion of mono-nucleated muscle
progenitor cells into the multi-nucleated muscle fiber syncytium. The temporally-controlled …

The MAPK p38α was proposed to be a prominent promoter of skeletal muscle aging. The
skeletal muscle tissue is composed of various muscle types, and it is not known if p38α is …

The pathogenesis of sarcopenia includes the dysfunction of calcium homeostasis
associated with the sarcoplasmic reticulum; however, the localization in sarcoplasmic …

BACKGROUND: Muscle aging is closely related to various epigenetic changes, and
exercise has a certain regulatory effect on these epigenetic changes. However, the specific …