Hedgehog Signaling: Implications in Liver Pathophysiology

RK Dutta, JH Jun, K Du, AM Diehl - Seminars in Liver Disease, 2023 - thieme-connect.com
The purpose of this review is to summarize current knowledge about the role of the
Hedgehog signaling pathway in liver homeostasis and disease. Hedgehog is a …

Exploring molecular mechanisms, therapeutic strategies, and clinical manifestations of Huntington's disease

A Shafie, AA Ashour, S Anwar, F Anjum… - Archives of Pharmacal …, 2024 - Springer
Huntington's disease (HD) is a paradigm of a genetic neurodegenerative disorder
characterized by the expansion of CAG repeats in the HTT gene. This extensive review …

[HTML][HTML] The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

K Maiese - Frontiers in Immunology, 2023 - frontiersin.org
Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …

Microglia: Formidable Players in Alzheimer's Disease and Other Neurodegenerative Disorders

K Maiese - Current Neurovascular Research, 2023 - ingentaconnect.com
Microglia account for approximately fifteen percent of the cell population in the brain and
spinal cord. These cells, considered to be family members of glial cells, have an active role …

[HTML][HTML] Dopamine in the Regulation of Glucose Homeostasis, Pathogenesis of Type 2 Diabetes, and Chronic Conditions of Impaired Dopamine Activity/Metabolism …

G Lisco, A De Tullio, M Iovino, O Disoteo… - Biomedicines, 2023 - mdpi.com
Dopamine regulates several functions, such as voluntary movements, spatial memory,
motivation, sleep, arousal, feeding, immune function, maternal behaviors, and lactation …

Mitochondria, mitophagy, Mitoptosis, and programmed cell death: implications from aging to cancer

K Maiese - Current Neurovascular Research, 2024 - ingentaconnect.com
Mitochondria are critical organelles in cells. Mitochondria are found in animal, fungi, and
plant cells and use aerobe respiration to provide energy to the cell through the generation of …

[HTML][HTML] Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK

K Maiese - Cells, 2023 - mdpi.com
Metabolic disorders and diabetes (DM) impact more than five hundred million individuals
throughout the world and are insidious in onset, chronic in nature, and yield significant …

Clinical Depression, the Mechanistic Target of Rapamycin (mTOR), and Forkhead Transcription Factors (FoxOs)

K Maiese - Current Neurovascular Research, 2023 - ingentaconnect.com
Depression is a disorder in the mental health of an individual that leads to a low level of
activity and feelings of despair and hopelessness [1-3]. Depression can lead to the inability …