Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …

Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an
increased possibility of adverse consequences such as falls, fractures, physical disabilities …

Senescent cells accumulate with age in vertebrates and promote aging largely through their
senescence‐associated secretory phenotype (SASP). Many types of stress induce …

Bigger animals live longer. The scaling exponent for the relationship between lifespan and
body mass is between 0.15 and 0.3. Bigger animals also expend more energy, and the …

The early observations on the rate-of-living theory by Max Rubner and the report by
Gershman that oxygen free radicals exist in vivo culminated in the seminal proposal in the …

Aging can be defined as progressive functional decline and increasing mortality over time.
Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates …

The oxidative stress theory of aging predicts that manipulations that alter oxidative
stress/damage will alter aging. The gold standard for determining whether aging is altered is …

Damage to the repository of genetic information in cells has plagued life since its very
beginning 3–4 billion years ago. Initially, in the absence of an ozone layer, especially …

Loss of genome maintenance may causally contribute to ageing, as exemplified by the
premature appearance of multiple symptoms of ageing in a growing family of human …

Given the central role of DNA in life, and how ageing can be seen as the gradual and
irreversible breakdown of living systems, the idea that damage to the DNA is the crucial …