[HTML][HTML] The immunology of SARS-CoV-2 infections and vaccines

L Grigoryan, B Pulendran - Seminars in immunology, 2020 - Elsevier
Abstract SARS-CoV-2, the virus that causes COVID-19, emerged in late 2019, and was
declared a global pandemic on March 11th 2020. With over 50 million cases and 1.2 million …

[HTML][HTML] A Research and Development (R&D) roadmap for influenza vaccines: Looking toward the future

KA Moore, JT Ostrowsky, AM Kraigsley, AJ Mehr… - Vaccine, 2021 - Elsevier
Improved influenza vaccines are urgently needed to reduce the burden of seasonal
influenza and to ensure a rapid and effective public-health response to future influenza …

The role of cell-mediated immunity against influenza and its implications for vaccine evaluation

Y Janssens, J Joye, G Waerlop, F Clement… - Frontiers in …, 2022 - frontiersin.org
Influenza vaccines remain the most effective tools to prevent flu and its complications.
Trivalent or quadrivalent inactivated influenza vaccines primarily elicit antibodies towards …

Immunosenescence and altered vaccine efficiency in older subjects: A myth difficult to change

T Fulop, A Larbi, G Pawelec, AA Cohen, G Provost… - Vaccines, 2022 - mdpi.com
Organismal ageing is associated with many physiological changes, including differences in
the immune system of most animals. These differences are often considered to be a key …

The status and prospects of Epstein–Barr virus prophylactic vaccine development

C Sun, X Chen, Y Kang, M Zeng - Frontiers in Immunology, 2021 - frontiersin.org
Epstein–Barr virus (EBV) is a human herpesvirus that is common among the global
population, causing an enormous disease burden. EBV can directly cause infectious …

Env exceptionalism: why are HIV-1 Env glycoproteins atypical immunogens?

PJ Klasse, G Ozorowski, RW Sanders, JP Moore - Cell host & microbe, 2020 - cell.com
Recombinant HIV-1 envelope (Env) glycoproteins of ever-increasing sophistication have
been evaluated as vaccine candidates for over 30 years. Structurally defined mimics of …

Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

P Riese, S Trittel, MK Akmatov, M May… - Nature …, 2022 - nature.com
Seasonal influenza outbreaks, especially in high-risk groups such as the elderly, represent
an important public health problem. Prevailing inadequate efficacy of seasonal vaccines is a …

The effect of influenza vaccine in reducing the severity of clinical outcomes in patients with COVID-19: a systematic review and meta-analysis

HW Almadhoon, A Hamdallah, SM Elsayed… - Scientific Reports, 2022 - nature.com
Recent evidence suggests that vaccination against influenza may reduce the clinical
outcomes of COVID-19. This study looked at the link between influenza vaccination and the …

Rational vaccine design in times of emerging diseases: The critical choices of immunological correlates of protection, vaccine antigen and immunomodulation

V Schijns, D Majhen, P Van Der Ley, A Thakur… - Pharmaceutics, 2021 - mdpi.com
Vaccines are the most effective medical intervention due to their continual success in
preventing infections and improving mortality worldwide. Early vaccines were developed …

Prophylactic and therapeutic ebv vaccines: Major scientific obstacles, historical progress, and future direction

J Cai, B Zhang, Y Li, W Zhu, T Akihisa, W Li, T Kikuchi… - Vaccines, 2021 - mdpi.com
The Epstein-Barr virus (EBV) infects more than 95% of adults worldwide and is associated
with various malignant tumors and immune diseases, imparting a huge disease burden on …