Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose–response data
J Menz, ME Götz, U Gündel, R Gürtler, K Herrmann… - Archives of …, 2023 - Springer
Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a
binary classification of chemical entities. For more than a decade, there has been a …
binary classification of chemical entities. For more than a decade, there has been a …
Genomic changes driven by radiation-induced DNA damage and microgravity in human cells
The space environment consists of a complex mixture of different types of ionizing radiation
and altered gravity that represents a threat to humans during space missions. In particular …
and altered gravity that represents a threat to humans during space missions. In particular …
Genetic and environmental associations of nonspecific chromosomal aberrations
K Hemminki, Y Niazi, L Vodickova, P Vodicka… - Mutagenesis, 2024 - academic.oup.com
Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating
lymphocytes from healthy individuals but the frequency may be higher after exposure to …
lymphocytes from healthy individuals but the frequency may be higher after exposure to …
Safety assessment of high fructose corn syrup and fructose used as sweeteners in foods
SN Bulbul, S Mamur, D Yuzbasioglu… - Toxicology mechanisms …, 2024 - Taylor & Francis
Abstract High Fructose Corn Syrup (HFCS) and Fructose (FR) are widely used sweeteners
in many foods and beverages. This study aimed at investigating the cytotoxic effects of …
in many foods and beverages. This study aimed at investigating the cytotoxic effects of …
Specific and shared biological functions of PARP2–is PARP2 really a lil'brother of PARP1?
PARP2, that belongs to the family of ADP-ribosyl transferase enzymes (ART), is a discovery
of the millennium, as it was identified in 1999. Although PARP2 was described initially as a …
of the millennium, as it was identified in 1999. Although PARP2 was described initially as a …
[HTML][HTML] Polymorphisms of the DNA repair genes (APE1, XPD, and RAD51) and the risk of developing cytogenetic abnormalities in a cohort of Egyptian patients with …
EH El-Noshokaty, GT Ebid, MA Ayoub… - The Egyptian Journal …, 2023 - journals.lww.com
Background Genetic alterations of the DNA repair genes might decrease the efficiency of
DNA repair mechanisms and increase susceptibility to cancers such as acute myeloid …
DNA repair mechanisms and increase susceptibility to cancers such as acute myeloid …