Implementation of personalized medicine services in community pharmacies: perceptions of independent community pharmacists

KM Alexander, HS Divine, CR Hanna, Y Gokun… - Journal of the American …, 2014 - Elsevier
Objectives To evaluate the perceptions of independent community pharmacists within a
regional independent community pharmacy cooperative on implementing personalized …

Individualized risk for statin-induced myopathy: current knowledge, emerging challenges and potential solutions

QP Feng, RA Wilke, TM Baye - Pharmacogenomics, 2012 - Taylor & Francis
Skeletal muscle toxicity is the primary adverse effect of statins. In this review, we summarize
current knowledge regarding the genetic and nongenetic determinants of risk for statin …

Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin

H Xu, M Jiang, M Oetjens, EA Bowton… - Journal of the …, 2011 - academic.oup.com
Objective DNA biobanks linked to comprehensive electronic health records systems are
potentially powerful resources for pharmacogenetic studies. This study sought to develop …

Cardiovascular pharmacogenomics

DM Roden, JA Johnson, SE Kimmel… - Circulation …, 2011 - Am Heart Assoc
Patients vary in their responses to drug therapy, and some of that variability is genetically
determined. This review outlines general approaches used to identify genetic variation that …

Drug response pharmacogenetics for 200,000 UK Biobank participants

G McInnes, RB Altman - BIOCOMPUTING 2021: Proceedings of the …, 2020 - World Scientific
Pharmacogenetics studies how genetic variation leads to variability in drug response.
Guidelines for selecting the right drug and right dose for patients based on their genetics are …

Efficient evaluation of prediction rules in semi-supervised settings under stratified sampling

J Gronsbell, M Liu, L Tian, T Cai - Journal of the Royal Statistical …, 2022 - academic.oup.com
In many contemporary applications, large amounts of unlabelled data are readily available
while labelled examples are limited. There has been substantial interest in semi-supervised …

CYP2C19 Loss‐of‐Function Variants Associated With Long‐Term Ischemic Stroke Events During Clopidogrel Treatment in the Chinese Population

P Wu, Z Liu, Z Tian, B Wu, J Shao, Q Li… - Clinical …, 2023 - Wiley Online Library
This study aims to determine whether CYP2C19 loss‐of‐function (LoF) variants were
associated with long‐term ischemic stroke risk in Chinese primary care patients treated with …

Semi-supervised approaches to efficient evaluation of model prediction performance

JL Gronsbell, T Cai - Journal of the Royal Statistical Society …, 2018 - academic.oup.com
In many modern machine learning applications, the outcome is expensive or time
consuming to collect whereas the predictor information is easy to obtain. Semi-supervised …

[HTML][HTML] Automated detection of altered mental status in emergency department clinical notes: a deep learning approach

JS Obeid, ER Weeda, AJ Matuskowitz… - BMC medical informatics …, 2019 - Springer
Background Machine learning has been used extensively in clinical text classification tasks.
Deep learning approaches using word embeddings have been recently gaining momentum …

Ethical issues in health research with novel online sources

E Vayena, A Mastroianni… - American journal of …, 2012 - ajph.aphapublications.org
Health-related research is increasingly drawing on novel sources of online data, such as
crowdsourced information about disease outbreaks, consumer-supplied information …