Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

Commensal microbes and their multicellular eukaryotic hosts constitute a highly integrated
system—termed the holobiont [1]—which undergoes dynamic changes through time as it …

A progressive loss of protein homeostasis is characteristic of aging and a driver of
neurodegeneration. To investigate this process quantitatively, we characterized proteome …

Despite many advances, metastatic disease remains essentially uncurable. Thus, there is an
urgent need to better understand mechanisms that promote metastasis, drive tumor …

Diapause is a state of suspended development that helps organisms survive extreme
environments. How diapause protects living organisms is largely unknown. Using the …

Radical lifespan disparities exist in the animal kingdom. While the ocean quahog can
survive for half a millennium, the mayfly survives for less than 48 h. The evolutionary …

The African turquoise killifish is an emerging vertebrate model organism with great potential
for aging research due to its naturally short lifespan. Thus far, turquoise killifish aging …

The African turquoise killifish is a powerful vertebrate system to study complex phenotypes
at scale, including aging and age-related disease. Here, we develop a rapid and precise …

Ephemeral habitats can impose challenging conditions for population persistence. Survival
strategies in these environments can range from high dispersal capacity to the evolution of …

The turquoise killifish, Nothobranchius furzeri, is a promising vertebrate model in ageing
research and an emerging model organism in genomics, regenerative medicine …