Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction

D Jia, Z Tian, R Wang - Ageing Research Reviews, 2023 - Elsevier
The benefits of regular physical activity are related to delaying and reversing the onset of
ageing and age-related disorders, including cardiomyopathy, neurodegenerative diseases …

Insights into the pathological basis of dementia from population‐based neuropathology studies

SB Wharton, JE Simpson, PG Ince… - Neuropathology and …, 2023 - Wiley Online Library
The epidemiological neuropathology perspective of population and community‐based
studies allows unbiased assessment of the prevalence of various pathologies and their …

[HTML][HTML] Characterization of hippocampal sclerosis of aging and its association with other neuropathologic changes and cognitive deficits in the oldest-old

L Sordo, T Qian, SA Bukhari, KM Nguyen… - Acta …, 2023 - Springer
Hippocampal sclerosis of aging (HS-A) is a common age-related neuropathological lesion
characterized by neuronal loss and astrogliosis in subiculum and CA1 subfield of …

Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles

P Sánchez-Juan, E Valeriano-Lorenzo… - Brain, 2024 - academic.oup.com
Glial fibrillary acidic protein (GFAP), a proxy of astrocyte reactivity, has been proposed as
biomarker of Alzheimer's disease. However, there is limited information about the correlation …

Past antihypertensive medication use is associated with lower levels of small vessel disease and lower Aβ plaque stage in the brains of older individuals

AJ Affleck, PS Sachdev… - … and Applied Neurobiology, 2023 - Wiley Online Library
Aims This study assesses the association of antihypertensive medication use on the
severities of neuropathological cerebrovascular disease (CVD excluding lobar infarction) in …

Associations of the A/T/N profiles in PET, CSF, and plasma biomarkers with Alzheimer's disease neuropathology at autopsy

ZB Wang, L Tan, PY Gao, YH Ma, Y Fu… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION To examine the extent to which positron emission tomography (PET)‐,
cerebrospinal fluid (CSF)‐, and plasma‐related amyloid‐β/tau/neurodegeneration (A/T/N) …

Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia

M Sargurupremraj, A Soumaré, JC Bis… - JAMA Network …, 2024 - jamanetwork.com
Importance Vascular disease is a treatable contributor to dementia risk, but the role of
specific markers remains unclear, making prevention strategies uncertain. Objective To …

[HTML][HTML] Alcohol Use Disorder and Dementia: A Review

NM Zahr - Alcohol Research: Current Reviews, 2024 - ncbi.nlm.nih.gov
PURPOSE By 2040, 21.6% of Americans will be over age 65, and the population of those
older than age 85 is estimated to reach 14.4 million. Although not causative, older age is a …

Associations of hospital-treated infections with subsequent dementia: nationwide 30-year analysis

LS Richmond-Rakerd, MT Iyer, S D'Souza, L Khalifeh… - Nature Aging, 2024 - nature.com
Infections, which can prompt neuroinflammation, may be a risk factor for dementia,,,–. More
information is needed concerning associations across different infections and different …

[HTML][HTML] Traffic-related air pollution and dementia incidence in the Adult Changes in Thought Study

MN Blanco, RM Shaffer, G Li, SD Adar, M Carone… - Environment …, 2024 - Elsevier
Background While epidemiologic evidence links higher levels of exposure to fine particulate
matter (PM 2.5) to decreased cognitive function, fewer studies have investigated links with …