Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

The goal of this review is to provide further understanding of increased vascular stiffness
with aging, and how it contributes to the adverse effects of major human diseases …

Sexual dimorphism is a key factor to consider in the ageing process given the impact that it
has on life expectancy. The oxidative-inflammatory theory of ageing states that the ageing …

Background Translating aging rejuvenation strategies into clinical practice has the potential
to address the unmet needs of the global aging population. However, to successfully do so …

Hypertension is the leading risk factor for cardiovascular disease and premature death
among women globally. However, there is a fundamental lack of knowledge regarding the …

Sex differences in aging occur in many animal species, and they include sex differences in
lifespan, in the onset and progression of age‐associated decline, and in physiological and …

Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …

The ovary ages earlier than most other tissues, yet the underlying mechanisms remain
elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in …

Biological sex is a factor in many conditions, including aging, neurodegenerative disease,
cancer, and more. For each of these, men and women display distinct differences in disease …