Chromosome instability (CIN) has been repeatedly associated with aging and progeroid
phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic …

By definition, aging is a natural, gradual and continuous process. On the other hand, frailty
reflects the increase in vulnerability to stressors and shortens the time without disease …

Due to intact reactive oxygen species homeostasis and glucose metabolism, C57BL/6NRj
mice are especially suitable to study cellular alterations in metabolism. We applied Nuclear …

Inflammaging refers to the age-related low grade, sterile, chronic, systemic, and long-lasting
subclinical, proinflammatory status, currently recognized as the main risk factor for …

Background The COVID-19 pandemic has highlighted the urgent need to understand
variation in immunosenescence at the population-level. Thus far, population patterns of …

For their stability and detectability faecal microRNAs represent promising molecules with
potential clinical interest as non-invasive diagnostic and prognostic biomarkers. However …

Aging markedly increases cancer risk, yet our mechanistic understanding of how aging
influences cancer initiation is limited. Here we demonstrate that the loss of ZNRF3, an …

Prenatal alcohol exposure (PAE) can reprogram the development of cells and tissues,
resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately …

Background Acute kidney injury (AKI) after noncardiac surgery is common and has
substantial health impact. Preclinical and clinical studies examining the influence of sex on …

Cardiometabolic diseases (CMDs) are a major cause of mortality worldwide, yet men and
women present remarkable differences in disease prognosis, onset and manifestation. Here …