SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

Risk factors of severe COVID-19: a review of host, viral and environmental factors

L Zsichla, V Müller - Viruses, 2023 - mdpi.com
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Impact of Dietary Fiber on Inflammation and Insulin Resistance in Older Patients: A Narrative Review

M Niero, G Bartoli, P De Colle, M Scarcella, M Zanetti - Nutrients, 2023 - mdpi.com
The beneficial impact of dietary fiber on the prevention and management of several chronic
conditions associated with aging, including diabetes, neurodegenerative, cardiovascular …

Changes of gut microbiota under different nutritional methods in elderly patients with severe COVID-19 and their relationship with prognosis

J Zhang, J Deng, J Li, Y Su, J Hu, D Lin, M Su… - Frontiers in …, 2023 - frontiersin.org
Background The clinical progression of individuals afflicted with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection exhibits significant heterogeneity …

[HTML][HTML] The renin-angiotensin system as a component of biotrauma in acute respiratory distress syndrome

K Krenn, V Tretter, F Kraft, R Ullrich - Frontiers in Physiology, 2022 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is a major concern in critical care medicine with
a high mortality of over 30%. Injury to the lungs is caused not only by underlying …

Emerging Vistas for the Nutraceutical Withania somnifera in Inflammaging

V Basudkar, G Gujrati, S Ajgaonkar, M Gandhi… - Pharmaceuticals, 2024 - mdpi.com
Inflammaging, a coexistence of inflammation and aging, is a persistent, systemic, low-grade
inflammation seen in the geriatric population. Various natural compounds have been greatly …

[PDF][PDF] Understanding the host-pathogen evolutionary balance through Gaussian process modeling of SARS-CoV-2

S Loguercio, BC Calverley, C Wang, D Shak, P Zhao… - Patterns, 2023 - cell.com
We have developed a machine learning (ML) approach using Gaussian process (GP)-based
spatial covariance (SCV) to track the impact of spatial-temporal mutational events driving …

Antibody and transcription landscape in peripheral blood mononuclear cells of elderly adults over 70 years of age with third dose of COVID-19 BBIBP-CorV and …

Y Zhang, L Zhao, J Zhang, X Zhang, S Han, Q Sun… - Immunity & …, 2024 - Springer
Background In the context of the COVID-19 pandemic and extensive vaccination, it is
important to explore the immune response of elderly adults to homologous and …

Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters

L Delval, A Hantute-Ghesquier, V Sencio, JM Flaman… - Nature Aging, 2023 - nature.com
Older age is one of the strongest risk factors for severe COVID-19. In this study, we
determined whether age-associated cellular senescence contributes to the severity of …

Potential use of endemic human coronaviruses to stimulate immunity against pathogenic SARS-CoV-2 and its variants

NS Shamabadi, AB Bagasra, S Pawar… - Libyan Journal of …, 2023 - Taylor & Francis
While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes significant
morbidity and mortality in humans, there is a wide range of disease outcomes following virus …