A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low …

Human beings have been recently reviewed as 'metaorganisms' as a result of a close
symbiotic relationship with the intestinal microbiota. This assumption imposes a more …

Given the dramatic increase in ageing populations, it is of great importance to understand
the genetic and molecular determinants of healthy ageing and longevity. Semi …

В монографии проанализированы основные концепции о природе старения, история
их возникновения и эволюция. Изложены современные представления о …

The immune system of an organism is an essential component of the defense mechanism
aimed at combating pathogenic stress. Age-associated immune dysfunction, also dubbed …

Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …

Accumulating data are documenting an inverse relationship between immune status,
response to vaccination, health, and longevity, suggesting that the immune system becomes …

Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme
decades of human life avoided or largely postponed all major age-related diseases. In this …

Background: The aging phenotype in humans is very heterogeneous and can be described
as a complex mosaic resulting from the interaction of a variety of environmental, stochastic …

This article examines the trend over time in the measures of “typical” longevity experienced
by members of a population: life expectancy at birth, and the median and modal ages at …