Tumours can obtain nutrients and oxygen required to progress and metastasize through the
blood supply. Inducing angiogenesis involves the sprouting of established vessel beds and …

Transcription factors (TFs), transcription co-factors (TcoFs) and their target genes perform
essential functions in diseases and biological processes. KnockTF 2.0 (http://www …

Cardiac fibrosis is associated with an adverse prognosis in cardiovascular disease that
results in a decreased cardiac compliance and, ultimately, heart failure. Recent studies have …

Abstract The 2023 Nucleic Acids Research Database Issue contains 178 papers ranging
across biology and related fields. There are 90 papers reporting on new databases and 82 …

In animal models, Nipbl deficiency phenocopies gene expression changes and birth defects
seen in Cornelia de Lange syndrome, the most common cause of which is Nipbl …

Gene regulatory networks (GRNs) are interpretable graph models encompassing the
regulatory interactions between transcription factors (TFs) and their downstream target …

Small nuclear RNAs (snRNAs) are structural and functional cores of the spliceosome. In
metazoan genomes, each snRNA has multiple copies/variants, up to hundreds in mammals …

Chromatin accessibility plays a critical role in the regulation of cell fate decisions. Although
gene expression changes have been extensively profiled at the single-cell level during early …

Neuronal and behavioral adaptations to novel stimuli are regulated by temporally dynamic
waves of transcriptional activity, which shape neuronal function and guide enduring …

Tumor bioinformatics plays an important role in cancer research and precision medicine.
The primary focus of traditional cancer research has been molecular and clinical studies of a …