[HTML][HTML] Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (MAM) dysfunction in diabetic kidney disease

Y Liu, Y Qiao, S Pan, J Chen, Z Mao… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Diabetic kidney disease (DKD) is a global health issue that presents a complex
pathogenesis and limited treatment options. To provide guidance for precise therapies, it is …

Podocyte-targeted therapies—progress and future directions

K Meliambro, JC He, KN Campbell - Nature Reviews Nephrology, 2024 - nature.com
Podocytes are the key target cells for injury across the spectrum of primary and secondary
proteinuric kidney disorders, which account for up to 90% of cases of kidney failure …

[HTML][HTML] S100A8/A9hi neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis

Y Wang, Y Shi, Y Shao, X Lu, H Zhang, C Miao - Cell Death & Disease, 2024 - nature.com
Abstract S100a8/a9, largely released by polymorphonuclear neutrophils (PMNs), belongs to
the S100 family of calcium-binding proteins and plays a role in a variety of inflammatory …

[HTML][HTML] Transcriptomic and machine learning analyses identify hub genes of metabolism and host immune response that are associated with the progression of …

Y Mao, X Hou, S Fu, J Luan - Genes & diseases, 2024 - Elsevier
Capsular contracture is a prevalent and severe complication that affects the postoperative
outcomes of patients who receive silicone breast implants. At present, prosthesis …

Predicting the Progress of Tuberculosis by Inflammatory Response‐Related Genes Based on Multiple Machine Learning Comprehensive Analysis

S Ma, P Peng, Z Duan, Y Fan… - Journal of Immunology …, 2023 - Wiley Online Library
Background. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis,
affects approximately one‐quarter of the global population and is considered one of the …

[HTML][HTML] Signaling by Type I Interferons in Immune Cells: Disease Consequences

M Zannikou, EN Fish, LC Platanias - Cancers, 2024 - mdpi.com
Simple Summary IFNs are cytokines that play critical roles in the immune defense
mechanisms that prevent virus spread. They also exhibit regulatory effects on the immune …

[HTML][HTML] ITGAM-mediated macrophages contribute to basement membrane damage in diabetic nephropathy and atherosclerosis

Y Lou, PH Li, XQ Liu, TX Wang, YL Liu, CC Chen… - BMC nephrology, 2024 - Springer
Background Diabetic nephropathy (DN) and atherosclerosis (AS) are prevalent and severe
complications associated with diabetes, exhibiting lesions in the basement membrane, an …

Identification of mitophagy‐related biomarkers in osteoarthritis

S Ruan, D Tang, Y Luo, H Song - Animal Models and …, 2024 - Wiley Online Library
Background Osteoarthritis (OA) is a common joint disease, and existing drugs cannot cure
OA, so there is an urgent need to identify new targets. Mitophagy plays an important role in …

Exploration of mitochondrial autophagy related genes in the diagnosis model construction and molecular marker mining of Alzheimer's disease based on multi-omics …

S Wang, J Zhang, H Zhang, Y Yang… - Cellular and Molecular …, 2024 - cellmolbiol.org
Key features of Alzheimer's disease include neuronal loss, accumulation of beta-amyloid
plaques, and formation of neurofibrillary tangles. These changes are due in part to abnormal …

Immune Escape and Metabolic Reprogramming in Colon Cancer: Insights from Endocytosis-Related Genes

Y Qin, Y Mao, Y Han, K Cheng, J Shi - BIO Web of Conferences, 2024 - bio-conferences.org
Colon cancer (COAD) is a common malignancy, yet its etiology is not fully elucidated. This
study gathered endocytosis-related genes, using gene expression profiles from TCGA …