Recent advances in methods to culture pluripotent stem cells to model human development
have resulted in entities that increasingly have recapitulated advanced stages of early …

Recent years have seen exciting progress across human embryo research, including new
methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …

The placenta is a unique organ system that functionally combines both maternal and fetal
cell types with distinct lineage origins. Normal placentation is critical for developmental …

Our ability to study early human post-implantation development remains highly limited due
to the ethical and technical challenges associated with intrauterine development of the …

The application of synthetic biology approaches to study development opens the possibility
to build and manipulate developmental processes to understand them better. Researchers …

Biotissues are intriguing systems that have long been imitated but never surpassed due to
their complex rhythms and undisclosed participation mechanisms of the interior aqueous …

Early embryo development is a highly dynamic process that plays a crucial role in
determining the health and characteristics of an organism. For many years, embryonic and …

Recently, 2 branches of the wide area of synthetic biology—in vitro gametogenesis and
synthetic embryo development—have gained considerable attention. Rodent induced …

Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts
termed blastoids upon switch to inductive medium. However, the underlying mechanisms …

The murine embryonic–trophoblast–extra-embryonic endoderm (ETX) model is an
integrated stem cell–based model to study early postimplantation development. It is based …