[HTML][HTML] COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

S Sinha, V Castillo, CR Espinoza, C Tindle… - …, 2022 - thelancet.com
Background In the aftermath of Covid-19, some patients develop a fibrotic lung disease, ie,
post-COVID-19 lung disease (PCLD), for which we currently lack insights into pathogenesis …

[HTML][HTML] Understanding the driving forces that trigger mutations in SARS-CoV-2: mutational energetics and the role of arginine blockers in COVID-19 therapy

H Ridgway, CT Chasapis, K Kelaidonis, I Ligielli… - Viruses, 2022 - mdpi.com
SARS-CoV-2 is a global challenge due to its ability to mutate into variants that spread more
rapidly than the wild-type virus. Because the molecular biology of this virus has been studied …

Senescence of alveolar epithelial progenitor cells: A critical driver of lung fibrosis

T Parimon, P Chen, BR Stripp, J Liang… - … of Physiology-Cell …, 2023 - journals.physiology.org
Pulmonary fibrosis comprises a range of chronic interstitial lung diseases (ILDs) that impose
a significant burden on patients and public health. Among these, idiopathic pulmonary …

[HTML][HTML] The dual role of oxidative-stress-induced autophagy in cellular senescence: Comprehension and therapeutic approaches

P Pantelis, G Theocharous, N Lagopati, D Veroutis… - Antioxidants, 2023 - mdpi.com
The contemporary lifestyle of the last decade has undeniably caused a tremendous increase
in oxidative-stress-inducing environmental sources. This phenomenon is not only connected …

[HTML][HTML] Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2

H Ridgway, GJ Moore, T Mavromoustakos… - Computational and …, 2022 - Elsevier
The discovery and facile synthesis of a new class of sartan-like arterial antihypertensive
drugs (angiotensin receptor blockers [ARBs]), subsequently referred to as “bisartans” is …

Treatment with the senolytics dasatinib/quercetin reduces SARS‐CoV‐2‐related mortality in mice

A Pastor‐Fernández, AR Bertos, A Sierra‐Ramírez… - Aging …, 2023 - Wiley Online Library
The enormous societal impact of the ongoing COVID‐19 pandemic has been particularly
harsh for some social groups, such as the elderly. Recently, it has been suggested that …

[HTML][HTML] Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis

S Zhou, J Zhu, PK Zhou, Y Gu - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Radiation-induced pulmonary fibrosis (RIPF) is a chronic and progressive respiratory tract
disease characterized by collagen deposition. The pathogenesis of RIPF is still unclear …

Repair of acute respiratory distress syndrome in COVID-19 by stromal cells (REALIST-COVID Trial): a multicenter, randomized, controlled clinical trial

EA Gorman, J Rynne, HJ Gardiner… - American Journal of …, 2023 - atsjournals.org
Rationale: Mesenchymal stromal cells (MSCs) may modulate inflammation, promoting repair
in coronavirus disease (COVID-19)–related acute respiratory distress syndrome (ARDS) …

[HTML][HTML] Contribution of viral and bacterial infections to senescence and immunosenescence

A Reyes, G Ortiz, LF Duarte, C Fernández… - Frontiers in cellular …, 2023 - frontiersin.org
Cellular senescence is a key biological process characterized by irreversible cell cycle
arrest. The accumulation of senescent cells creates a pro-inflammatory environment that can …

Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways

D Veroutis, OD Argyropoulou, AV Goules… - Annals of the …, 2024 - ard.bmj.com
Objectives Age is the strongest risk factor of giant cell arteritis (GCA), implying a possible
pathogenetic role of cellular senescence. To address this question, we applied an …