A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer

I Mourkioti, A Polyzou, D Veroutis… - Journal of Experimental …, 2023 - Springer
Background Prostate cancer is a major cause of cancer morbidity and mortality in men
worldwide. Androgen deprivation therapy (ADT) has proven effective in early-stage …

SARS-CoV-2 and the DNA damage response

RJ Grand - Journal of General Virology, 2023 - microbiologyresearch.org
The recent coronavirus disease 2019 (COVID-19) pandemic was caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …

Increase of HO-1 expression in critically ill COVID-19 patients is associated with poor prognosis and outcome

MG Detsika, I Nikitopoulou, D Veroutis, AG Vassiliou… - Antioxidants, 2022 - mdpi.com
Heme-oxygenase (HO)-1 is a cytoprotective enzyme with strong antioxidant and anti-
apoptotic properties and previous reports have also emphasized the antiviral properties of …

Deferiprone: a forty-year-old multi-targeting drug with possible activity against COVID-19 and diseases of similar symptomatology

GJ Kontoghiorghes - International Journal of Molecular Sciences, 2022 - mdpi.com
The need for preparing new strategies for the design of emergency drug therapies against
COVID-19 and similar diseases in the future is rather urgent, considering the high rate of …

Long COVID and the neuroendocrinology of microbial translocation outside the GI tract: some treatment strategies

A Sfera, C Osorio, S Hazan, Z Kozlakidis… - Endocrines, 2022 - mdpi.com
Similar to previous pandemics, COVID-19 has been succeeded by well-documented post-
infectious sequelae, including chronic fatigue, cough, shortness of breath, myalgia, and …

Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly

Z Li, M Tian, G Wang, X Cui, J Ma, S Liu… - Frontiers in Cellular …, 2023 - frontiersin.org
In the context of the global COVID-19 pandemic, the phenomenon that the elderly have
higher morbidity and mortality is of great concern. Existing evidence suggests that …

An impact of age on respiratory syncytial virus infection in air-liquid-interface culture bronchial epithelium

K Ito, L Daly, M Coates - Frontiers in Medicine, 2023 - frontiersin.org
Background Elderly people are known to be vulnerable to virus infection. However, this has
not been appropriately tested in in vitro studies due to a lack of appropriate virus infection …

Epigenetics of SARS-CoV2 (COVID-19)

S Rawat, R Gilhotra, SK Singh, AA Bhat, A Ojha… - Targeting epigenetics in …, 2023 - Springer
The study of genetic differences in gene activity without alterations to DNA sequences is
referred to as “epigenetics.” The focus of this extremely new field of research is on the …

Self-DNA driven inflammation in COVID-19 and after mRNA-based vaccination: lessons for non-COVID-19 pathologies

M Heil - Frontiers in Immunology, 2024 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented
concentration of economic and research efforts to generate knowledge at unequalled speed …

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages

K Hönzke, B Obermayer, C Mache… - European …, 2022 - Eur Respiratory Soc
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilises the
angiotensin-converting enzyme 2 (ACE2) transmembrane peptidase as cellular entry …