Background The identification of critically ill COVID-19 patients at risk of fatal outcomes
remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers …

Background Several risk factors have been involved in the poor clinical progression of
coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may …

The global coronavirus disease 2019 (COVID-19) pandemic has caused major morbidity,
mortality and socioeconomic disruption on an individual and collective level. Over 6 million …

It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …

SARS-CoV-2 infection can manifest as a wide range of respiratory and systemic symptoms
well after the acute phase of infection in over 50% of patients. Key questions remain on the …

Patients with pulmonary fibrosis (PF) often experience exacerbations of their disease,
characterised by a rapid, severe deterioration in lung function that is associated with high …

Background Pre-existing hypertensive pathologies are linked to worsened outcomes in
patients infected with severe-acute respiratory syndrome (SARS-CoV-2). Sartans, a family of …

Life expectancy is increasing worldwide, and by 2050 the proportion of the world's
population over 65 years of age is estimated to surpass 1.5 billion. Kidney aging is …

Aim Senescence of alveolar type II (AT2) cells is an important driver of pulmonary fibrosis.
This study aimed to investigate whether and how dysregulation of hydrogen sulfide (H2S) …

Older age is one of the strongest risk factors for severe COVID-19. In this study, we
determined whether age-associated cellular senescence contributes to the severity of …