LATE‐NC in Alzheimer's disease: Molecular aspects and synergies
Alzheimer's disease (AD) is classically characterized by senile plaques and neurofibrillary
tangles (NFTs). However, multiple copathologies can be observed in the AD brain and …
tangles (NFTs). However, multiple copathologies can be observed in the AD brain and …
Cognitive symptoms progress with limbic-predominant age-related TDP-43 encephalopathy stage and co-occurrence with Alzheimer disease
S Hiya, C Maldonado-Díaz, JM Walker… - … of Neuropathology & …, 2024 - academic.oup.com
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) is a neuropathologic entity characterized by transactive response DNA-binding protein …
NC) is a neuropathologic entity characterized by transactive response DNA-binding protein …
Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) is detectable at autopsy in more than one-third of people beyond age 85 years and is …
NC) is detectable at autopsy in more than one-third of people beyond age 85 years and is …
In severe ADNC, hippocampi with comorbid LATE-NC and hippocampal sclerosis have substantially more astrocytosis than those with LATE-NC or hippocampal …
DM Niedowicz, Y Katsumata… - … of Neuropathology & …, 2023 - academic.oup.com
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) and hippocampal sclerosis of aging (HS-A) pathologies are found together at autopsy …
NC) and hippocampal sclerosis of aging (HS-A) pathologies are found together at autopsy …
[HTML][HTML] Pathologic correlates of aging-related tau astrogliopathy: ARTAG is associated with LATE-NC and cerebrovascular pathologies, but not with ADNC
Age-related tau astrogliopathy (ARTAG) is detectable in the brains of over one-third of
autopsied persons beyond age 80, but the pathoetiology of ARTAG is poorly understood …
autopsied persons beyond age 80, but the pathoetiology of ARTAG is poorly understood …
[HTML][HTML] Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer's Coordinating Center database
DC Woodworth, KM Nguyen, L Sordo… - Acta …, 2024 - Springer
TDP-43 proteinopathy is a salient neuropathologic feature in a subset of frontotemporal
lobar degeneration (FTLD-TDP), in amyotrophic lateral sclerosis (ALS-TDP), and in limbic …
lobar degeneration (FTLD-TDP), in amyotrophic lateral sclerosis (ALS-TDP), and in limbic …
[HTML][HTML] Longitudinal hippocampal atrophy in hippocampal sclerosis of aging
Hippocampal sclerosis of aging (HS-A) is a common degenerative neuropathology in older
individuals and is associated with dementia. HS-A is characterized by disproportionate …
individuals and is associated with dementia. HS-A is characterized by disproportionate …
Limbic-predominant age-related TDP-43 encephalopathy in the oldest old: a population-based study
E Mikhailenko, K Colangelo, J Tuimala, M Kero… - Brain, 2024 - academic.oup.com
Population-based cohort studies are essential for understanding the pathological basis of
dementia in older populations. Previous studies have shown that limbic-predominant age …
dementia in older populations. Previous studies have shown that limbic-predominant age …
Amygdala-predominant α-synuclein pathology exacerbates hippocampal neuron loss in Alzheimer's disease
Misfolded α-synuclein (αSyn) protein accumulates in 43-63% of individuals with
symptomatic Alzheimer's disease (AD). Two main patterns of co-morbid αSyn pathology …
symptomatic Alzheimer's disease (AD). Two main patterns of co-morbid αSyn pathology …