The biology of ergothioneine, an antioxidant nutraceutical

I Borodina, LC Kenny, CM McCarthy… - Nutrition Research …, 2020 - cambridge.org
Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …

[HTML][HTML] Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia

R Marín, DI Chiarello, C Abad, D Rojas… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

[HTML][HTML] Ergothioneine, recent developments

IK Cheah, B Halliwell - Redox biology, 2021 - Elsevier
There has been a recent surge of interest in the unique low molecular weight dietary
thiol/thione, ergothioneine. This compound can accumulate at high levels in the body from …

Prolonging healthy aging: longevity vitamins and proteins

BN Ames - Proceedings of the National Academy of …, 2018 - National Acad Sciences
It is proposed that proteins/enzymes be classified into two classes according to their
essentiality for immediate survival/reproduction and their function in long-term health: that is …

Ergothioneine–a diet‐derived antioxidant with therapeutic potential

B Halliwell, IK Cheah, RMY Tang - FEBS letters, 2018 - Wiley Online Library
Ergothioneine is a thiol/thione molecule synthesised only by some fungi and bacteria.
Nonetheless, it is avidly taken up from the diet by humans and other animals through a …

Diet-derived antioxidants: the special case of ergothioneine

B Halliwell, RMY Tang, IK Cheah - Annual Review of Food …, 2023 - annualreviews.org
This article reviews what is presently known about the biological roles of the diet-derived
compound ergothioneine (ET). ET seems important to humans because it is rapidly taken up …

A microbial transporter of the dietary antioxidant ergothioneine

DG Dumitrescu, EM Gordon, Y Kovalyova… - Cell, 2022 - cell.com
Summary Low-molecular-weight (LMW) thiols are small-molecule antioxidants required for
the maintenance of intracellular redox homeostasis. However, many host-associated …

[HTML][HTML] Bio-funcional components in mushrooms, a health opportunity: Ergothionine and huitlacohe as recent trends

GA Martinez-Medina, ML Chávez-González… - Journal of Functional …, 2021 - Elsevier
Macrofungi, mushrooms or higher fungi have been employed for medicinal and food
purposes for decades, nevertheless, also represent, a novel and fruitful source of …

Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites

T Teruya, YJ Chen, H Kondoh… - Proceedings of the …, 2021 - National Acad Sciences
Dementia is caused by factors that damage neurons. We quantified small molecular markers
in whole blood of dementia patients, using nontargeted liquid chromatography–mass …

Reactive oxygen species (ROS), oxygen radicals and antioxidants: Where are we now, where is the field going and where should we go?

B Halliwell - Biochemical and biophysical research communications, 2022 - Elsevier
The field of oxygen free radicals, antioxidants and reactive oxygen species (ROS) has
exploded in the past few decades, and BBRC has published several seminal papers. ROS …