Liquid chromatography coupled with high-resolution mass spectrometry (LC–HRMS) has
become a workhorse in global metabolomics studies with growing applications across …

Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and a
potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated …

Recently, increasing evidence has suggested the association between gut dysbiosis and
Alzheimer's disease (AD) progression, yet the role of gut microbiota in AD pathogenesis …

6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist that suppresses cancer cell
metabolism but concurrently enhances the metabolic fitness of tumor CD8+ T cells. DON …

Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the
idea that a molecular clock is necessary for metabolic homeostasis. However, these mice …

Although much work has linked the human microbiome to specific phenotypes and lifestyle
variables, data from different projects have been challenging to integrate and the extent of …

Activated T cells differentiate into functional subsets with distinct metabolic programs.
Glutaminase (GLS) converts glutamine to glutamate to support the tricarboxylic acid cycle …

The lysosome degrades and recycles macromolecules, signals to the cytosol and nucleus,
and is implicated in many diseases. Here, we describe a method for the rapid isolation of …

The role of adaptive immunity in early cancer development is controversial. Here we show
that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver …