Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …

Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …

Mapping single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …

COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

The community of cells lining our airways plays a collaborative role in the preservation of
immune homeostasis in the lung and provides protection from the pathogens and pollutants …

The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model …

The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …

The population is aging at a rate never seen before in human history. As the number of
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …

Methods for profiling genes at the single-cell level have revolutionized our ability to study
several biological processes and systems including development, differentiation, response …