Coccidioidomycosis, otherwise known as Valley Fever, is caused by the dimorphic fungi
Coccidioides immitis and C. posadasii. While most clinical cases present with self-limiting …

Predicting patient features from single-cell data can unveil cellular states implicated in
health and disease. Linear models and average cell type expressions are typically favored …

Precise splice junction calls are currently unavailable in scRNA-seq pipelines such as the
10x Chromium platform but are critical for understanding single-cell biology. Here, we …

Alveolar epithelial type II (AT2) cells secrete pulmonary surfactant via lamellar bodies (LBs).
Abnormalities in LBs are associated with pulmonary disorders, including fibrosis. However …

Respiratory diseases account for over 5 million deaths yearly and are a huge burden to
healthcare systems worldwide. Murine models have been of paramount importance to …

Genomics methods have uncovered patterns in a range of biological systems, but obscure
important aspects of cell behavior: the shape, relative locations of, movement of, and …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal degenerative lung disease of
unknown etiology. Although in its final stages it implicates, in a reactive manner, all lung cell …

Ex-utero regulation of the lungs' responses to breathing air and continued alveolar
development shape adult respiratory health. Applying single-cell transposome …

The increased resolution of single-cell RNA-sequencing technologies has led to major
breakthroughs and improved our understanding of the normal and pathologic conditions of …

Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …