Lung cancer is regarded as one of the most lethal diseases endangering human survival. It
is difficult to detect lung cancer in its early stages, because of the ambiguity in the lung …

Respiratory failure is the leading cause of COVID-19 death and disproportionately impacts
adults more than children. Here, we present a large-scale snATAC-seq dataset (90,980 …

Although epithelial-mesenchymal transition (EMT) is a common feature of fibrotic lung
disease, its role in fibrogenesis is controversial. Recently, aberrant basaloid cells were …

The human body consists of 37 trillion single cells represented by over 50 organs that are
stitched together to make us who we are, yet we still have very little understanding about the …

Background: Although studies suggest a deficiency in stem cell numbers in chronic airway
diseases such as chronic obstructive pulmonary disease (COPD), the role of bronchial …

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels
responsible for rapid neural and neuromuscular signal transmission. Although it is well …

The complex cellular heterogeneity of the lung poses a unique challenge to researchers in
the field. While the use of bulk RNA sequencing has become a ubiquitous technology in …

Abstract In three‐dimensional (3D) space, an unbiased and systemic view of human
specimens between structures and functions is required. However, conventional histological …

Background Refractory asthma (RA) remains poorly controlled, resulting in high health care
utilization despite guideline-based therapies. Patients with RA manifest higher neutrophilia …

Abstract Alpha 1-antitrypsin (AAT) deficiency, a hereditary disorder characterized by low
serum levels of functional AAT, is associated with early development of panacinar …