Coccidioidomycosis, otherwise known as Valley Fever, is caused by the dimorphic fungi
Coccidioides immitis and C. posadasii. While most clinical cases present with self-limiting …

Although significant strides have been made in the understanding of pulmonary
immunology, much work remains to be done to comprehensively explain coordinated …

Background Interstitial lung disease (ILD) includes many rare and often poorly understood
heterogeneous diseases that cause fibrosis and/or inflammation of the lungs. ILDs are …

Precise splice junction calls are currently unavailable in scRNA-seq pipelines such as the
10x Chromium platform but are critical for understanding single-cell biology. Here, we …

Lung transplantation remains the only viable option for individuals suffering from end-stage
lung failure. However, a number of current limitations exist including a continuing shortage …

Background The hedgehog (HH) pathway has been associated with chronic obstructive
pulmonary disease (COPD) in genome-wide association studies and recent studies suggest …

Respiratory diseases account for over 5 million deaths yearly and are a huge burden to
healthcare systems worldwide. Murine models have been of paramount importance to …

Elevated arginases including type‐I (Arg‐I) and type‐II isoenzyme (Arg‐II) are reported to
play a role in aging, age‐associated organ inflammaging, and fibrosis. A role of arginase in …

Single-cell biology has revolutionized the way we understand biological processes. In this
paper, we provide a more tailored approach to clustering and analyzing spatial single-cell …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal degenerative lung disease of
unknown etiology. Although in its final stages it implicates, in a reactive manner, all lung cell …