Cellular barcodes are distinct DNA sequences that enable one to track specific cells across time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes …
Short-read sequencing is the workhorse of cancer genomics yet is thought to miss many structural variants (SVs), particularly large chromosomal alterations. To characterize missing …
Z Yao, N Xu, G Shang, H Wang, H Tao, Y Wang… - Nature …, 2023 - nature.com
The progression of urothelial bladder cancer (UC) is a complicated multi-step process. We perform a comprehensive multi-omics analysis of 448 samples from 190 UC patients …
F Jiang, Y Liu, Y Xue, P Cheng, J Wang, J Lian… - International …, 2023 - Elsevier
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and monkeypox virus (MPXV) severely threaten human health; however, currently, no vaccine …
R Shi, X Wang, Y Wu, B Xu, T Zhao, C Trapp… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide- like) family-mediated mutagenesis is widespread in human cancers. However, our …
M Shahab, S Aiman, A Alshammari, AF Alasmari… - International Journal of …, 2023 - Elsevier
Jamestown Canyon virus (JCV) is a deadly viral infection transmitted by various mosquito species. This mosquito-borne virus belongs to Bunyaviridae family, posing a high public …
Research on the immune system and cancer has led to the development of new medicines that enable the former to attack cancer cells. Drugs that specifically target and destroy …
S Peng, T Zhang, S Zhang, Q Tang, Y Yan… - Frontiers in …, 2022 - frontiersin.org
Background The etiopathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood, and there has been extensive interest in the interaction between inflammatory …
PA Ginno, H Borgers, C Ernst, A Schneider, M Behm… - Nature Genetics, 2024 - nature.com
How chronic mutational processes and punctuated bursts of DNA damage drive evolution of the cancer genome is poorly understood. Here, we demonstrate a strategy to disentangle …