Validation of biomarkers of aging
The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
DNA methylation aberrant in atherosclerosis
Y Dai, D Chen, T Xu - Frontiers in Pharmacology, 2022 - frontiersin.org
Atherosclerosis (AS) is a pathological process involving lipid oxidation, immune system
activation, and endothelial dysfunction. The activated immune system could lead to …
activation, and endothelial dysfunction. The activated immune system could lead to …
Per-and polyfluoroalkyl substances, epigenetic age and DNA methylation: a cross-sectional study of firefighters
JM Goodrich, MM Calkins, AJ Caban-Martinez… - …, 2021 - Taylor & Francis
Background: Per-and polyfluoroalkyl substances (PFASs) are persistent chemicals that
firefighters encounter. Epigenetic modifications, including DNA methylation, could serve as …
firefighters encounter. Epigenetic modifications, including DNA methylation, could serve as …
[HTML][HTML] Metal mixtures and DNA methylation measures of biological aging in American Indian populations
K Boyer, A Domingo-Relloso, E Jiang, K Haack… - Environment …, 2023 - Elsevier
Abstract Introduction Native American communities suffer disproportionately from elevated
metal exposures and increased risk for cardiovascular diseases and diabetes. DNA …
metal exposures and increased risk for cardiovascular diseases and diabetes. DNA …
Genetic evidence for causal effects of socioeconomic, lifestyle, and cardiometabolic factors on epigenetic-age acceleration
Abstract GrimAge acceleration (GrimAgeAccel) and PhenoAge acceleration
(PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging …
(PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging …
Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study
FM Berstein, DL McCartney, AT Lu, KK Tsilidis… - Elife, 2022 - elifesciences.org
Background: Epigenetic clocks have been associated with cancer risk in several
observational studies. Nevertheless, it is unclear whether they play a causal role in cancer …
observational studies. Nevertheless, it is unclear whether they play a causal role in cancer …
Cardiovascular disease and the biology of aging
S Moturi, SK Ghosh-Choudhary, T Finkel - Journal of Molecular and …, 2022 - Elsevier
The incidence and prevalence of a wide range of cardiovascular diseases increases as a
function of age. This well-established epidemiological relationship suggests that …
function of age. This well-established epidemiological relationship suggests that …
[HTML][HTML] Counteracting aged DNA methylation states to combat ageing and age-related diseases
A Reale, S Tagliatesta, G Zardo, M Zampieri - Mechanisms of Ageing and …, 2022 - Elsevier
DNA methylation (DNAm) overwrites information about multiple extrinsic factors on the
genome. Age is one of these factors. Age causes characteristic DNAm changes that are …
genome. Age is one of these factors. Age causes characteristic DNAm changes that are …
Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis
Y Yang, Z Xia, C Xu, C Zhai, X Yu, S Li - Frontiers in Pharmacology, 2022 - frontiersin.org
Background and Purpose: Ciprofol (HSK3486), a novel 2, 6-disubstituted phenol derivative,
is a new intravenous anesthetic compound with a similar chemical structure to propofol …
is a new intravenous anesthetic compound with a similar chemical structure to propofol …
From multi-omics approaches to personalized medicine in myocardial infarction
Myocardial infarction (MI) is a prevalent cardiovascular disease characterized by myocardial
necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe …
necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe …