Cathepsins and SARS‐CoV‐2 infection: From pathogenic factors to potential therapeutic targets

S Zhao, M Jiang, H Qing, J Ni - British Journal of Pharmacology, 2023 - Wiley Online Library
Abstract Coronavirus disease‐19 (COVID‐19) is caused by severe acute respiratory
syndrome‐coronavirus‐2 (SARS‐CoV‐2) infection. The COVID‐19 pandemic began in …

Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation

Y Jing, X Jiang, Q Ji, Z Wu, W Wang, Z Liu… - Cell Stem Cell, 2023 - cell.com
Our understanding of the molecular basis for cellular senescence remains incomplete,
limiting the development of strategies to ameliorate age-related pathologies by preventing …

[HTML][HTML] Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients

IC Schultz, APS Bertoni, MR Wink - Journal of Molecular Medicine, 2022 - Springer
For over a year, the coronavirus disease 2019 has been affecting the world population by
causing severe tissue injuries and death in infected people. Adenosine triphosphate (ATP) …

[HTML][HTML] Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach

DLM Fonseca, IS Filgueiras, AHC Marques, E Vojdani… - npj Aging, 2023 - nature.com
Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) severity due to
immunosenescence and certain age-dependent medical conditions (eg, obesity …

[HTML][HTML] A role of inflammaging in aortic aneurysm: new insights from bioinformatics analysis

S Wang, H Liu, P Yang, Z Wang, P Ye, J Xia… - Frontiers in …, 2023 - frontiersin.org
Introduction Aortic aneurysms (AA) are prevalent worldwide with a notable absence of drug
therapies. Thus, identifying potential drug targets is of utmost importance. AA often presents …

An integrative analysis of the single-cell transcriptome identifies DUSP4 as an exhaustion-associated gene in tumor-infiltrating CD8+ T cells

Y Zhao, H Cai, X Ding, X Zhou - Functional & Integrative Genomics, 2023 - Springer
CD8+ T cells play essential roles in antitumor and antiviral immune responses. The term T-
cell exhaustion was initially used to describe the functionally exhaustive phenotype of T cells …

SARS-CoV-2 infection induces the production of autoantibodies in severe COVID-19 patients in an age-dependent manner

DLM Fonseca, IS Filgueiras, AHC Marques, E Vojdani… - medRxiv, 2022 - medrxiv.org
Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) outcomes due to
immunosenescence and certain age-dependent medical conditions (eg, obesity …

[HTML][HTML] Plasma-free blood as a potential alternative to whole blood for transcriptomic analysis

Q Chen, X Guo, H Wang, S Sun, H Jiang, P Zhang… - Phenomics, 2023 - Springer
RNA sequencing (RNAseq) technology has become increasingly important in precision
medicine and clinical diagnostics, and emerged as a powerful tool for identifying protein …

Whole blood transcriptome analysis for age-and gender-specific gene expression profiling in Japanese individuals

Y Aoki, K Taguchi, H Anzawa… - The Journal of …, 2024 - academic.oup.com
Whole blood transcriptome analysis is a valuable approachin medical research, primarily
due to the ease of sample collection and the richness of the information obtained. Since the …

[HTML][HTML] Using genetics and proteomics data to identify proteins causally related to COVID-19, healthspan and lifespan: a Mendelian randomization study

JV Zhao, M Yao, Z Liu - Aging (Albany NY), 2024 - ncbi.nlm.nih.gov
Background: COVID-19 pandemic poses a heavy burden on public health and accounts for
substantial mortality and morbidity. Proteins are building blocks of life, but specific proteins …