Persistent brainstem dysfunction in long-COVID: a hypothesis

SJ Yong - ACS chemical neuroscience, 2021 - ACS Publications
Long-COVID is a postviral illness that can affect survivors of COVID-19, regardless of initial
disease severity or age. Symptoms of long-COVID include fatigue, dyspnea, gastrointestinal …

The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models

R Butowt, N Meunier, B Bryche, CS von Bartheld - Acta neuropathologica, 2021 - Springer
One of the most frequent symptoms of COVID-19 is the loss of smell and taste. Based on the
lack of expression of the virus entry proteins in olfactory receptor neurons, it was originally …

SARS-CoV-2 infection and persistence in the human body and brain at autopsy

SR Stein, SC Ramelli, A Grazioli, JY Chung, M Singh… - Nature, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction,–
during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

G Douaud, S Lee, F Alfaro-Almagro, C Arthofer… - Nature, 2022 - nature.com
There is strong evidence of brain-related abnormalities in COVID-19,,,,,,,,,,,–. However, it
remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder …

COVID-19 neuropathology at columbia university irving medical center/New York presbyterian hospital

KT Thakur, EH Miller, MD Glendinning, O Al-Dalahmah… - Brain, 2021 - academic.oup.com
Many patients with SARS-CoV-2 infection develop neurological signs and symptoms;
although, to date, little evidence exists that primary infection of the brain is a significant …

[HTML][HTML] Challenges in defining Long COVID: Striking differences across literature, Electronic Health Records, and patient-reported information

HM Rando, TD Bennett, JB Byrd, C Bramante… - MedRxiv, 2021 - ncbi.nlm.nih.gov
Since late 2019, the novel coronavirus SARS-CoV-2 has introduced a wide array of health
challenges globally. In addition to a complex acute presentation that can affect multiple …

[PDF][PDF] SARS-CoV-2 infection and persistence throughout the human body and brain

D Chertow, S Stein, S Ramelli, A Grazioli, JY Chung… - 2021 - academia.edu
COVID-19 is known to cause multi-organ dysfunction1-3 in acute infection, with 68
prolonged symptoms experienced by some patients, termed Post-Acute Sequelae of SARS …

Brain imaging before and after COVID-19 in UK Biobank

G Douaud, S Lee, F Alfaro-Almagro, C Arthofer… - MedRxiv, 2021 - medrxiv.org
There is strong evidence for brain-related pathologies in COVID-19, some of which could be
a consequence of viral neurotropism, or of neuroinflammation following viral infection. Most …

APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical …

SN Kurki, J Kantonen, K Kaivola, L Hokkanen… - Acta neuropathologica …, 2021 - Springer
Apolipoprotein E ε4 allele (APOE4) has been shown to associate with increased
susceptibility to SARS-CoV-2 infection and COVID-19 mortality in some previous genetic …

Assessing brain capillaries in coronavirus disease 2019

DW Nauen, JE Hooper, CM Stewart… - JAMA neurology, 2021 - jamanetwork.com
Methods| The institutional review boards of Johns Hopkins University and Mass General
Brigham approved this study, and the next of kin of each patient consented for use of tissues …