Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics

R Thapa, M Afzal, A Goyal, G Gupta, AA Bhat… - Life sciences, 2024 - Elsevier
Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a
discouragingly low survival rate and few effective treatments. An important function of the …

Glioblastoma therapy: past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

PANoptosis-based molecular subtyping and HPAN-index predicts therapeutic response and survival in hepatocellular carcinoma

F Song, CG Wang, JZ Mao, TL Wang, XL Liang… - Frontiers in …, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC) is a highly prevalent and fatal cancer. The role
of PANoptosis, a novel form of programmed cell death, in HCC is yet to be fully understood …

Current opportunities for targeting dysregulated neurodevelopmental signaling pathways in glioblastoma

D Drakulic, M Schwirtlich, I Petrovic, M Mojsin… - Cells, 2022 - mdpi.com
Glioblastoma (GBM) is the most common and highly lethal type of brain tumor, with poor
survival despite advances in understanding its complexity. After current standard therapeutic …

Integrative analysis of a novel super-enhancer-associated lncRNA prognostic signature and identifying LINC00945 in aggravating glioma progression

Z Yang, Y Zheng, H Wu, H Xie, J Zhao, Z Chen, L Li… - Human Genomics, 2023 - Springer
Abstract Background Super-enhancers (SEs), driving high-level expression of genes with
tumor-promoting functions, have been investigated recently. However, the roles of super …

Unlocking the predictive potential of long non-coding RNAs: a machine learning approach for precise cancer patient prognosis

Y Mo, J Adu-Amankwaah, W Qin, T Gao, X Hou… - Annals of …, 2023 - Taylor & Francis
The intricate web of cancer biology is governed by the active participation of long non-
coding RNAs (lncRNAs), playing crucial roles in cancer cells' proliferation, migration, and …

Combination of multiple omics techniques for a personalized therapy or treatment selection

C Massa, B Seliger - Frontiers in Immunology, 2023 - frontiersin.org
Despite targeted therapies and immunotherapies have revolutionized the treatment of
cancer patients, only a limited number of patients have long-term responses. Moreover, due …

[HTML][HTML] Prognostic significance and mechanisms of CXCL genes in clear cell renal cell carcinoma

J Shen, R Wang, Y Chen, Z Fang, J Tang, J Yao… - Aging (albany …, 2023 - ncbi.nlm.nih.gov
This study aimed to investigate the clinical significance, biological functions, and underlying
mechanisms of CXCL genes in clear cell renal cell carcinoma (ccRcc) based on patient …

A TGF‐β signaling‐related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response

WW Duan, LT Yang, J Liu, ZY Dai… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims The dysregulation of TGF‐β signaling is a crucial pathophysiological process in
tumorigenesis and progression. LncRNAs have diverse biological functions and are …

Systematic integration of m6A regulators and autophagy-related genes in combination with long non-coding RNAs predicts survival in glioblastoma multiforme

A Sharma, Y Wang, F Ge, P Chen, TC Dakal… - Scientific Reports, 2023 - nature.com
Glioblastoma multiforme (GBM) is probably the only tumor in which a unique epigenetic
alteration, namely methylation of the MGMT gene, possesses direct clinical relevance. Now …