Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Numerous studies have shown that epigenetic age—an individual's degree of aging based
on patterns of DNA methylation—can be computed and is associated with an array of factors …

The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …

Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue
dysfunction and disease. At the cellular level, ageing is associated with reduced function …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Several interventions have recently emerged that were proposed to reverse rather than just
attenuate aging, but the criteria for what it takes to achieve rejuvenation remain …

Aging is characterized by functional decline occurring alongside changes to several
hallmarks of aging. One of the hallmarks includes attrition of repeated DNA sequences …

Background Biological age is a measure of health that offers insights into ageing. The
existing age clocks, although valuable, often trade off accuracy and interpretability. We …

There is no single universal biomarker yet to estimate overall health status and longevity
prospects. Moreover, a consensual approach to the very concept of aging and the means of …

Aging clocks have provided one of the most important recent breakthroughs in the biology of
aging, and may provide indicators for the effectiveness of interventions in the aging process …