Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

This review focuses on the multiple and reciprocal relationships that exist between oxidative
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …

Historically, cancer research and therapy have focused on malignant cells and their tumor
microenvironment. However, the vascular, lymphatic and nervous systems establish long …

Regular physical activity is associated with lower cancer incidence and mortality, as well as
with a lower rate of tumour recurrence. The epidemiological evidence is supported by …

Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of
oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular …

Background Despite a clear link between aging and cancer, there has been inconclusive
evidence on how biological age (BA) may be associated with cancer incidence. Methods We …

Aging is characterized by progressive functional deterioration with increased risk of
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …

As aging and tumorigenesis are tightly interconnected biological processes, targeting their
common underlying driving pathways may induce dual‐purpose anti‐aging and anti‐cancer …

As life expectancy increases in many countries, the prevalence of age-related diseases also
rises. Among these conditions, chronic kidney disease is predicted to become the second …

Non-pituitary growth hormone (npGH) expression is well established in extrapituitary
tissues, but an understanding of the physiological role of npGH remains rather limited. Pro …